C-prenylation of 1,3 dihydroxyxanthone: synthesis, characterization and antibacterial activity

Authors

  • Emmy Yuanita UNIVERSITAS MATARAM
  • Baiq Khaeratul Jannah Department of Chemistry, Faculty of Science, University of Mataram
  • Maria Ulfa Department of Chemistry, Faculty of Science, University of Mataram
  • Sudirman Department of Chemistry, Faculty of Science, University of Mataram
  • Baiq Nila Sari Ningsih Department of Chemistry, Faculty of Science, University of Mataram
  • Ni Komang Tri Dharmayani Department of Chemistry, Faculty of Science, University of Mataram

DOI:

https://doi.org/10.29303/aca.v6i1.149

Keywords:

1,3-dihydroxyxanthone, 1,3-dihydroxy-2-prenylxanthone, prenylation, antibacterial

Abstract

Prenylated 1,3-dihydroxyxanthone has been successfully synthesized using Prenyl bromide and KOH. Characterization of the synthesized compound using Infra Red (IR) and Nuclear Magnetic Resonance (1H-NMR) showed that monosubstituted c-prenylation was occurred at carbon number 2 to form 1,3-dihydroxy-2-prenylxanthone. The synthesis result was a yellow-brown paste with a yield of 43.09%. This prenylated 1,3-dihydroxyxanthone had moderate antibacterial activity against Escherichia coli with an inhibition zone > 5 mm at a concentration of 15%.

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C-Prenylation of 1,3 Dihydroxyxanthone

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Published

2023-02-25

How to Cite

Yuanita, E. ., Jannah, B. K. ., Ulfa, M. ., Sudirman, Ningsih, B. N. S. ., & Dharmayani , N. K. T. . (2023). C-prenylation of 1,3 dihydroxyxanthone: synthesis, characterization and antibacterial activity. Acta Chimica Asiana, 6(1), 279–286. https://doi.org/10.29303/aca.v6i1.149

Issue

Vol. 6 No. 1 (2023)

Section

Articles

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Copyright (c) 2023 Emmy Yuanita, Baiq Khaeratul Jannah, Maria Ulfa, Sudirman, Baiq Nila Sari Ningsih, Ni Komang Tri Dharmayani

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