Binding studies of ruthenium complexes with antithyroid drug
Penulis
Dinosha Dinosha , George Allen Gnana Raj , Thangadurai Sumitha CelinDOI:
10.29303/aca.v7i2.213Diterbitkan:
2024-10-31Terbitan:
Vol 7 No 2 (2024)Kata Kunci:
hormones, drug, antithyroid, Benesi-Hildebrand plot, thyronorm, emissionArticles
Unduhan
Cara Mengutip
Unduhan
Metrik
Abstrak
Medicinal substances are essential to our daily existence. A prudent approach to metal complexation with already available medications may result in more stylish, intelligent, and effective drug compositions. Thus, the binding of [Ru(NN)3]2+ (NN = 2,2ˈ-bipyridine, 1,10-phenanthroline) with the antithyroid medication thyronorm has been studied in the current attempt. The use of absorption and emission spectrum techniques allowed researchers to examine the complexes' interactions with antithyroid medications. Studies of absorption and emission spectra show that the complex and medication interact through coordinated ligand hydrophobic and hydrogen bonding interactions.Analysis has also been done on the binding of the antithyroid medication Thyronorm to ruthenium complexes. The Benesi-Hildebrand plot was used to determine the binding constants of the drug complexes. Current research indicates that the Thyronorm pill has good affinity with [Ru(phen)3]2+complex.
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Biografi Penulis
Dinosha Dinosha, Scott Christian College(Autonomous), Nagercoil, Tamilnadu, India
student
George Allen Gnana Raj, Scott Christian College(Autonomous), Nagercoil, Tamilnadu, India
Associate Professor of Chemistry
Lisensi
Hak Cipta (c) 2024 D S Berlin Dinosha, George Allen Gnana Raj, Thangadurai Sumitha Celin
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