Binding studies of ruthenium complexes with antithyroid drug

Authors

  • D S Berlin Dinosha Scott Christian College(Autonomous), Nagercoil, Tamilnadu, India
  • George Allen Gnana Raj Scott Christian College(Autonomous), Nagercoil, Tamilnadu, India
  • Thangadurai Sumitha Celin Scott Christian College(Autonomous) NagercoilTamilnadu, India

DOI:

https://doi.org/10.29303/aca.v7i2.213

Keywords:

hormones, drug, antithyroid, Benesi-Hildebrand plot, thyronorm, emission

Abstract

Medicinal substances are essential to our daily existence. A prudent approach to metal complexation with already available medications may result in more stylish, intelligent, and effective drug compositions. Thus, the binding of [Ru(NN)3]2+ (NN = 2,2ˈ-bipyridine, 1,10-phenanthroline) with the antithyroid medication thyronorm has been studied in the current attempt. The use of absorption and emission spectrum techniques allowed researchers to examine the complexes' interactions with antithyroid medications. Studies of absorption and emission spectra show that the complex and medication interact through coordinated ligand hydrophobic and hydrogen bonding interactions.Analysis has also been done on the binding of the antithyroid medication Thyronorm to ruthenium complexes. The Benesi-Hildebrand plot was used to determine the binding constants of the drug complexes. Current research indicates that the Thyronorm pill has good affinity with [Ru(phen)3]2+complex.

 

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Author Biographies

D S Berlin Dinosha, Scott Christian College(Autonomous), Nagercoil, Tamilnadu, India

student

George Allen Gnana Raj, Scott Christian College(Autonomous), Nagercoil, Tamilnadu, India

Associate Professor of Chemistry

References

Soares L,A., Sardi J., Gullo F,P., Pitangui N,S., Scorzoni, L., Leite FS, et al.(2013). Anti dermatophytic therapy - prospects for the discovery of new drugs from natural products. Braz J Microbiol, 44,1035–41.

Islahudin, F, Tindall,S,M., Mellor, I,R., Swift, K., Christensen HEM, Fone KCF, et al(2014). The antimalarial drug quinine interferes with serotonin biosynthesis and action. Sci Rep [Internet]. 4(1):3618.

Maury, P., Rollin, A., Galinier, M., Juillière,Y.,(2014). Role of digoxin in controlling the ventricular rate during a trial fibrillation: a systematic review and a rethinking. Research Reports in Clinical Cardiology. 5,93–101.

Chraïbi, A., Renauld,S.,(2014).PPARγ-induced stimulation of amiloride-sensitive sodium current in renal collecting duct principal cells is serum and insulin dependent. Cell PhysiolBiochem. 33(3),581–93.

Grazul, M., Budzisz.E.,(2009). Biological activity of metal ions complexes of chromones, coumarins and flavones. Coord Chem Rev.253(21–22),2588–98.

Ni, Y., Du, S., Kokot,S.,(2007). Interaction between quercetin-copper (II) complex and DNA with the use of the Neutral Red dye fluorophor probe. Analytica Chimica Acta. 584,19–27.

Etman, M.A., Salama,R,O., Shamsedeen, M,A., El-Kamel, A.,(2001). Solubilization of etodolac for parenteral administration. Indian J Pharm Sci. 63,459–67.

Li, P., Zhao L., Yalkowsky, S,H.,(1999). Combined effect of co solvent and cyclodextrin on solubilization of nonpolar drugs. J Pharm Sci.88,967–9.

Nielsen, A,B., Frydenvang, K., Liljefors, T., Buur, A., Larsen, C.,(2005). Assessment of the combined approach of N-alkylation and salt formation to enhance aqueous solubility of tertiary amines using bupivacaine as a model drug. Eur J Pharm Sci.24(1),85–93.

Otsuka, M., Matsuda,Y.,(1995) Effect of cogrinding with various kinds of surfactants on the dissolution behaviour of phenytoin. JPharm Sci. 84,1434–7.

Kumar,N,K., Murali, M., Prasad, C.,(2002).Himasankar K, Murthy VR. Comparative studies on the effect of some hydrophilic polymers on the dissolution rate of a poorly water-soluble drug meloxicam. Indian Drugs. 39(6),323–9.

Corvi,M,P., Cirri, M., Uekama, A,B., Fujinaga, K., Hirayama, T., Otagiri, F., et al.(1984). Enhancement of solubility and bioavailability by ternary complexation with β-cyclodextrin and glycine. J Pharm Sci. 92,1338–41.

Uekama, K., Fujinaga, T., Hirayama, F., Otagiri, M., Yamasaki, M., Seo, H., et al.(1983). Improvement of the oral bioavailability of digitalis glycosides by cyclodextrin complexation. J Pharm Sci.72(11),1338–41.

Duan, L., Mandal,F,B., Stewart, S., Privalov, B., Liobet, T., Sun, A., et al.(2011). A molecular ruthenium catalyst with water - oxidation activity comparable to that of photosystem II. Chemical Communications. 4,12607–9.

Chen, Z., Chen, C., Weinberg,D,R., Kang, P., Concepcion, J,J., Harrison, D,P., et al. (2011). Electrocatalytic reduction of CO2 to CO by polypyridyl ruthenium complexes. Chem Commun (Camb),47(47),12607–9.

Ohzu, S., Ishizuko, T., Hirai, Y., Fukuzum, S., Kojima,T.,(2013). Photocatalytic oxidation of organic compounds in water by using Ruthenium polypyridylamine complexes as catalysts with high efficiency and selectivity. An European Journal. 19,1563–7.

Muthu Mareeswaran, P., Babu, E., Rajagopal,S.,(2013). Optical recognition of anions by ruthenium (II) bipyridine - calyx [4] arene system. Journal of Fluorescence. 23,997–1006.

Babu, E., Muthu Mareeswaran, P., Rajagopal,S.,(2013). Highly sensitive optical biosensor for thrombin based on structure switching aptamer luminescent silica nanoparticles. Journal of Fluorescence. 23,137–46.

Muthu Mareeswaran, P., Maheshwara, D., Balu, E., Rajagopal,S.,(2012). Binding and Fluorescence, resonance energy transfer (FRET) of Ruthenium(II)bipyridine - calixarene system with proteins - experimental and docking studies. Journal of Fluorescence. 22,1345–56.

Taheri, S., Behzad, M., Nazari, H., Khaleghian,A.,(2013). Synthesis, characterization and biological studies of new Ruthenium polypyridyl complexes containing non innocent ligands. ISRN Inorganic Chemistry. 2013,1–6.

Gill,M,R., Thomas, J,R.,(2012). Ruthenium (II) Polypyridyl complexes and DNA - from structural probes to cellular imaging and therapeutics. Chemical Society Reviews. 41,3179–92.

Zhennan Zhao, Xiang Zhang , Chang-e Li , Tianfeng Chen(2019). Designing luminescent ruthenium prodrug for precise cancer therapy and rapid clinical diagnosis.Biomaterials.192,579-589.

Leipoldt,J,G., Lamprecht, G,J., Steynberg, E,C., (1991). Kinetics of the substitution of Acetylacetone in acetylactonate-1,5- cyclooctadiene rhodium (I) by derivatives of 1,10-Phenanthroline and 2,2’-dipyridyl. Journal of organometallic Chemistry. 402(2).

Sumitha Celin, T, Gnana Raj,A.,(2017), Micellar Effect on the Photoinduced Electron Transfer Reactions of Ruthenium (II)-Polypyridyl Complexes with Quinones. Journal of Chemical and Material Research. 6(2,3),1294–300.

Saha, B., Stanbury,D,M.,(2000). Thermal and Photochemical Reduction of Aqueous Chlorine by Ruthenium (II) Polypyridyl Complexes. Inorganic Chemistry.39,1294–300.

Binding studies of  ruthenium complexes with antithyroid drug

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Published

2024-10-31

How to Cite

Dinosha, D. S. B. ., Allen Gnana Raj, G., & Sumitha Celin, T. (2024). Binding studies of ruthenium complexes with antithyroid drug. Acta Chimica Asiana, 7(2), 509–516. https://doi.org/10.29303/aca.v7i2.213

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