Acta Chimica Asiana <p><strong>Acta Chimica Asiana&nbsp;</strong>(online&nbsp;<a href=";1489059749&amp;1&amp;&amp;">ISSN 2550-0503</a>, print&nbsp;<a href=";1489064854&amp;1&amp;&amp;">ISSN 2550-049x</a>)&nbsp;is a peer-reviewed, open access journal that publishes high-quality original research articles as well as review articles in all areas of Chemistry, including Chemical Education and Chemical Engineering. Significant finding that is insufficient to be presented as comprehensive paper but needs to reach the reader immediately may also be submitted as a short communication. The editors welcome original contributions that have not been published and are not under consideration elsewhere. This journal is published by Chemistry Education Program, the University of Mataram.&nbsp;All papers published free of charge. Upon request, language assistance may also be provided to ensure valuable works in chemistry meet their readers.</p> <p>Acta Chimica Asiana has been Accredited by the Ministry of Research, Technology and Higher Education of The Republic of Indonesia. The recognition published in Director Decree No.85/M/KPT/2020.</p> en-US <h4>Authors who publish with ACA: Acta Chimica Asiana agree to the following terms:</h4> <ol type="a"> <li>Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a <strong><a href="" target="_blank" rel="license noopener">Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License</a></strong>. This license allows authors to use all articles, data sets, graphics, and appendices in data mining applications, search engines, web sites, blogs, and other platforms by providing an appropriate reference. The journal allows the author(s) to hold the copyright without restrictions and will retain publishing rights without restrictions.</li> <li>Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in <a href="">ACA: Acta Chimica Asiana</a>.</li> <li>Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See <a href="" target="_new">The Effect of Open Access</a>).</li> </ol> <p> </p> (Lalu Rudyat Telly Savalas) (Saprizal Hadisaputra) Sat, 31 Dec 2022 00:00:00 +0800 OJS 60 Free radical scavenging actions of virgin coconut oil <p>Natural antioxidants are quite popular in beauty products. In further product development, natural antioxidants are needed from local products of the NTB community. This study aims to optimize the antioxidant activity of local products Virgin Coconut Oil (VCO) from <em>Cocos nucifera</em> L. grown in Lombok. This type of research is experimental laboratory research using the DPPH method. VCO was isolated by conventional methods, namely standing and layered filtration. Data were obtained from the results of the UV-Vis spectroscopy test. The results showed that the free radical inhibition of VCO was strong, with an IC50 value of 51.57 and an inhibition of 48% at a 5% VCO concentration. The absorbance of DPPH decreased with increasing reaction time. The decrease in absorbance from every 5 minutes indicates the antioxidant activity continues to a stationary point. A color change indicates the stationary point to yellow. The strong antioxidant activity of VCO is used as the basis for its use as an active ingredient in various cosmetic products. VCO is also believed to have a function as a natural moisturizer.</p> Jono Irawan, Aliefman Hakim, Saprizal Hadisaputra Copyright (c) 2022 Jono Irawan, Aliefman Hakim, Saprizal Hadisaputra Tue, 12 Jul 2022 00:00:00 +0800 Effect of oxygen heteroatom on sensor-cyanide anions binding <p>The study aims to analyze the effect of heteroatom replacement on benzimidazole derivative chemosensor compounds on the ability to form hydrogen bonds with anions. In this case, the N heteroatom in the benzimidazole derivative sensor compound (S1) is replaced with the O heteroatom to become a benzoxazole derivative sensor compound (S3). Calculating the energy of the molecules involved in the electron level gives the following results: replacing heteroatoms with more electronegative atoms increases the HOMO energy of the sensor molecules, making the sensor more reactive to anions and strengthening the binding of the sensor with cyanide anions.</p> R Rahmawati, Fara Dwirani Sofia Copyright (c) 2022 R Rahmawati, Fara Dwirani Sofia Fri, 23 Dec 2022 00:00:00 +0800 Effect of Different Calcium Salts on Calcium Carbonates Formation Induced by Halophilic Bacillus oceanisediminis CB1 <p>Biomineralization through the biomimetic CO<sub>2 </sub>sequestration process has been gaining attraction in recent years due to the formation of carbonates widely used as raw material in various industrial processes. The deposition and dissolution of calcium carbonate can be affected by physiochemical factors, such as the type of calcium salt. However, most studies have focused on calcium chloride (CaCl<sub>2</sub>). In the present study, A potent bacterial carbonic anhydrase (CA) producer, <em>Bacillus oceanisediminis</em> CB1, was screened on CA activity from mangrove plant <em>Avicennia marina,</em> collected from Ghogha, Bhavnagar, India (21.68°N 72.28°E). We premeditated deposition experiments to determine the effects of different calcium salts on calcium carbonate deposition in <em>Bacillus oceanisediminis</em> CB1 colonies. The results demonstrated the calcite formation observed in calcium salt-supplemented nutrient agar, calcium chloride, and calcium acetate. Merely uniform distribution and peripheral distribution of calcite particles found in calcium acetate and calcium chloride supplemented into nutrient agar, respectively. Calcite formation was confirmed by staining with Alizarin Red S dye followed by SEM-EDX. This study will provide a vital reference for designing and applying microbial-induced carbonate precipitation using different calcium salts.</p> Chintan Bhagat, Sunil Bhavsar, Rajesh Patel, Anjana Ghelani, Pravin Dudhagara, Rajesh Chaudhari Copyright (c) 2022 Chintan Bhagat, Sunil Bhavsar, Rajesh Patel, Anjana Ghelani, Pravin Dudhagara, Rajesh Chaudhari Sat, 31 Dec 2022 00:00:00 +0800 Identification of Active Compound from Mitragyna speciosa Leave as Antiinflammation Agent: In Silico Study. <p>The study aims to identify the most responsible compound for the antiinflammation activity from <em>Mitragyna speciosa </em>leaves. Seventeen compounds previously reported to have been isolated from the leave were virtually screened against human 5-lipoxygenase protein and analyzed according to their binding energies. The native ligand used was arachidonic acid, and mitragynine was found to be the strongest binding compound (Pubchem ID: 3034396). In addition, ADMET profiling shows that mitragynine was not violating Lipinski’s rule of five and was not toxic.</p> Ihsanul Arief, Erwan Kurnianto Copyright (c) 2022 Ihsanul Arief, Erwan Kurnianto Sat, 31 Dec 2022 00:00:00 +0800 Design of Reactor for the Production of Zinc Ferrite <p>The development and analysis of a reactor design for the manufacture of zinc ferrite is the aim of this study. The design employs a Continuous Stirred Tank Reactor (CSTR) type, with the tank and stirrer serving as the reactor's primary structural elements. The requirements for the built tank and stirrer will significantly impact the safety and production of silicon dioxide. As a result, Microsoft Excel is used for the calculation process for designing this reactor. The results of the calculations are obtained for design pressure 4,304 psig, cylinder thickness 0.07 in, top cover thickness 0.07 in, top cover height 12.39 in, bottom cover thickness 0.08 in, bottom cover height 21.18 in, reactor height 44.34 in, impeller length 5.43 in, stirring power 5 hp and shaft length 15.98 in. This design can become a reference for the production of zinc ferrite to make it more efficient in the production process.</p> Fathiyah Afriani Anshari, Asep Bayu Dani Nandiyanto, Risti Ragaditha Copyright (c) 2022 Fathiyah Afriani Anshari, Asep Bayu Dani Nandiyanto, Risti Ragaditha Sat, 31 Dec 2022 00:00:00 +0800 In Vitro and Silico Antibacterial Activity Evaluation Jackfruit Parasite Plant Macrosolencochinchinensis (Lour.) van Tiegh <p>In traditional Melayu Riau medicine, the jackfruit parasite plant, also known as Macrosolen cochinchinensis (Lour.) van Tiegh, has been utilized as a remedy for coughs, a treatment for cancer, a diuretic, and to speed up the recovery process after giving birth. Through in vitro and in silico testing, this investigation aims to learn more about the bioactive components and antibacterial activity of n-hexane, ethyl acetate, and ethanol obtained from the extracts of the jackfruit parasite plant (Macrosolen cochinchinensis (Lour.) van Tiegh. The disc diffusion method was used for the in vitro testing, and the molecular docking method was used for the in silico testing. Both were conducted against Staphylococcus aureus ATCC 12600 and Escherichia coli ATCC 25922. Each sample extract was prepared in three different concentrations (10%, 30%, and 50%), while chloramphenicol was used as the positive control. Inhibition zones of the extract against E. coli bacteria were found to be as follows: 6 mm, 8.4 mm, and 10.6 mm for the n-hexane extract; 8.2 mm, 10.7 mm, and 15.6 mm for the ethyl acetate extract; and 6 mm, 7.1 mm, and 14.1 mm for the methanol extract. The results of the test to determine the extract's antibacterial activity were as follows: The following is a list of the zones of inhibition that the extract has against S. aureus bacteria: 6 mm, 7.5 mm, and 13.7 mm in diameter for the extract of n-hexane; 12.8 mm, 14.2 mm, and 19.2 mm in diameter for the extract of ethyl acetate. Test results of 7.2 mm, 9.3 mm, and 15.3 mm were obtained for the methanol extract. In accordance with the findings of the study, the ethyl acetate extract of jackfruit parasite leaves exhibited the highest level of antibacterial activity, as measured by an inhibition zone diameter of 19.2 mm, when tested on S. aureus bacteria. In the meantime, the results of molecular docking of punicalin and rutin, which have been reported to have activity against proteins 6GOS.pdb and 1OJZ.pdb, have potential as antibacterials because they form 5 and 9 hydrogen bonds with important amino acids of the target protein, with cDOCKER values of -57.9239 and -88.3993, respectively. It suggests that punicalin and rutin can inhibit the growth of bacteria.</p> Rahmiwati Hilma, Suma Rahmani Harahap, Jufrizal Syahri Copyright (c) 2022 Rahmiwati Hilma, Suma Rahmani Harahap, Jufrizal Syahri Sat, 31 Dec 2022 00:00:00 +0800 The Effect of Using Augmented Reality-Based Learning Media on Chemistry Students’ Conceptual Understanding on Molecular Shape <p>This study aims to examine the effect of using Augmented Reality-based learning media on students' conceptual understanding of molecular shape material. This research is a quasi-experimental study with a post-test-only design. The class used was class X Mathematics and Natural Sciences in one of the Bengkulu City High Schools, which received molecular shape material, consisting of 1 control class and 1 experimental class. The control class is a class that uses PowerPoint media as usual with 2-dimensional image visualization. In contrast, the experimental class is a class that uses augmented reality-based learning media with 3-dimensional visualization. The instrument used is a post-test instrument referring to conceptual understanding indicators. The results were analyzed using a t-test. The results of the analysis showed that the significance level was 0.002. This result indicates that it is smaller than the significance level, or it can be concluded that there is a significant difference in the average understanding of the concept between the control class and the experimental class.</p> Febrian Solikhin, Dewi Handayani , Salastri Rohiat Copyright (c) 2023 Febrian Solikhin, Dewi Handayani , Salastri Rohiat Sat, 31 Dec 2022 00:00:00 +0800