Acta Chimica Asiana 2022-12-31T00:00:00+08:00 Lalu Rudyat Telly Savalas Open Journal Systems <p><strong>Acta Chimica Asiana&nbsp;</strong>(online&nbsp;<a href=";1489059749&amp;1&amp;&amp;">ISSN 2550-0503</a>, print&nbsp;<a href=";1489064854&amp;1&amp;&amp;">ISSN 2550-049x</a>)&nbsp;is a peer-reviewed, open access journal that publishes high-quality original research articles as well as review articles in all areas of Chemistry, including Chemical Education and Chemical Engineering. Significant finding that is insufficient to be presented as comprehensive paper but needs to reach the reader immediately may also be submitted as a short communication. The editors welcome original contributions that have not been published and are not under consideration elsewhere. This journal is published by Chemistry Education Program, the University of Mataram.&nbsp;All papers published free of charge. Upon request, language assistance may also be provided to ensure valuable works in chemistry meet their readers.</p> <p>Acta Chimica Asiana has been Accredited by the Ministry of Research, Technology and Higher Education of The Republic of Indonesia. The recognition published in Director Decree No.85/M/KPT/2020.</p> Free radical scavenging actions of virgin coconut oil 2022-06-22T23:33:10+08:00 Jono Irawan Aliefman Hakim Saprizal Hadisaputra <p>Natural antioxidants are quite popular in beauty products. In further product development, natural antioxidants are needed from local products of the NTB community. This study aims to optimize the antioxidant activity of local products Virgin Coconut Oil (VCO) from <em>Cocos nucifera</em> L. grown in Lombok. This type of research is experimental laboratory research using the DPPH method. VCO was isolated by conventional methods, namely standing and layered filtration. Data were obtained from the results of the UV-Vis spectroscopy test. The results showed that the free radical inhibition of VCO was strong, with an IC50 value of 51.57 and an inhibition of 48% at a 5% VCO concentration. The absorbance of DPPH decreased with increasing reaction time. The decrease in absorbance from every 5 minutes indicates the antioxidant activity continues to a stationary point. A color change indicates the stationary point to yellow. The strong antioxidant activity of VCO is used as the basis for its use as an active ingredient in various cosmetic products. VCO is also believed to have a function as a natural moisturizer.</p> 2022-07-12T00:00:00+08:00 Copyright (c) 2022 Jono Irawan, Aliefman Hakim, Saprizal Hadisaputra Effect of oxygen heteroatom on sensor-cyanide anions binding 2022-06-14T21:00:16+08:00 R Rahmawati Fara Dwirani Sofia <p>The study aims to analyze the effect of heteroatom replacement on benzimidazole derivative chemosensor compounds on the ability to form hydrogen bonds with anions. In this case, the N heteroatom in the benzimidazole derivative sensor compound (S1) is replaced with the O heteroatom to become a benzoxazole derivative sensor compound (S3). Calculating the energy of the molecules involved in the electron level gives the following results: replacing heteroatoms with more electronegative atoms increases the HOMO energy of the sensor molecules, making the sensor more reactive to anions and strengthening the binding of the sensor with cyanide anions.</p> 2022-12-23T00:00:00+08:00 Copyright (c) 2022 R Rahmawati, Fara Dwirani Sofia Effect of Different Calcium Salts on Calcium Carbonates Formation Induced by Halophilic Bacillus oceanisediminis CB1 2022-12-26T21:38:12+08:00 Chintan Bhagat Sunil Bhavsar Rajesh Patel Anjana Ghelani Pravin Dudhagara Rajesh Chaudhari <p>Biomineralization through the biomimetic CO<sub>2 </sub>sequestration process has been gaining attraction in recent years due to the formation of carbonates widely used as raw material in various industrial processes. The deposition and dissolution of calcium carbonate can be affected by physiochemical factors, such as the type of calcium salt. However, most studies have focused on calcium chloride (CaCl<sub>2</sub>). In the present study, A potent bacterial carbonic anhydrase (CA) producer, <em>Bacillus oceanisediminis</em> CB1, was screened on CA activity from mangrove plant <em>Avicennia marina,</em> collected from Ghogha, Bhavnagar, India (21.68°N 72.28°E). We premeditated deposition experiments to determine the effects of different calcium salts on calcium carbonate deposition in <em>Bacillus oceanisediminis</em> CB1 colonies. The results demonstrated the calcite formation observed in calcium salt-supplemented nutrient agar, calcium chloride, and calcium acetate. Merely uniform distribution and peripheral distribution of calcite particles found in calcium acetate and calcium chloride supplemented into nutrient agar, respectively. Calcite formation was confirmed by staining with Alizarin Red S dye followed by SEM-EDX. This study will provide a vital reference for designing and applying microbial-induced carbonate precipitation using different calcium salts.</p> 2022-12-31T00:00:00+08:00 Copyright (c) 2022 Chintan Bhagat, Sunil Bhavsar, Rajesh Patel, Anjana Ghelani, Pravin Dudhagara, Rajesh Chaudhari Identification of Active Compound from Mitragyna speciosa Leave as Antiinflammation Agent: In Silico Study. 2022-12-27T15:22:05+08:00 Ihsanul Arief Erwan Kurnianto <p>The study aims to identify the most responsible compound for the antiinflammation activity from <em>Mitragyna speciosa </em>leaves. Seventeen compounds previously reported to have been isolated from the leave were virtually screened against human 5-lipoxygenase protein and analyzed according to their binding energies. The native ligand used was arachidonic acid, and mitragynine was found to be the strongest binding compound (Pubchem ID: 3034396). In addition, ADMET profiling shows that mitragynine was not violating Lipinski’s rule of five and was not toxic.</p> 2022-12-31T00:00:00+08:00 Copyright (c) 2022 Ihsanul Arief, Erwan Kurnianto Design of Reactor for the Production of Zinc Ferrite 2022-12-26T21:20:04+08:00 Fathiyah Afriani Anshari Asep Bayu Dani Nandiyanto Risti Ragaditha <p>The development and analysis of a reactor design for the manufacture of zinc ferrite is the aim of this study. The design employs a Continuous Stirred Tank Reactor (CSTR) type, with the tank and stirrer serving as the reactor's primary structural elements. The requirements for the built tank and stirrer will significantly impact the safety and production of silicon dioxide. As a result, Microsoft Excel is used for the calculation process for designing this reactor. The results of the calculations are obtained for design pressure 4,304 psig, cylinder thickness 0.07 in, top cover thickness 0.07 in, top cover height 12.39 in, bottom cover thickness 0.08 in, bottom cover height 21.18 in, reactor height 44.34 in, impeller length 5.43 in, stirring power 5 hp and shaft length 15.98 in. This design can become a reference for the production of zinc ferrite to make it more efficient in the production process.</p> 2022-12-31T00:00:00+08:00 Copyright (c) 2022 Fathiyah Afriani Anshari, Asep Bayu Dani Nandiyanto, Risti Ragaditha In Vitro and Silico Antibacterial Activity Evaluation Jackfruit Parasite Plant Macrosolencochinchinensis (Lour.) van Tiegh 2022-12-29T10:08:20+08:00 Rahmiwati Hilma Suma Rahmani Harahap Jufrizal Syahri <p>In traditional Melayu Riau medicine, the jackfruit parasite plant, also known as Macrosolen cochinchinensis (Lour.) van Tiegh, has been utilized as a remedy for coughs, a treatment for cancer, a diuretic, and to speed up the recovery process after giving birth. Through in vitro and in silico testing, this investigation aims to learn more about the bioactive components and antibacterial activity of n-hexane, ethyl acetate, and ethanol obtained from the extracts of the jackfruit parasite plant (Macrosolen cochinchinensis (Lour.) van Tiegh. The disc diffusion method was used for the in vitro testing, and the molecular docking method was used for the in silico testing. Both were conducted against Staphylococcus aureus ATCC 12600 and Escherichia coli ATCC 25922. Each sample extract was prepared in three different concentrations (10%, 30%, and 50%), while chloramphenicol was used as the positive control. Inhibition zones of the extract against E. coli bacteria were found to be as follows: 6 mm, 8.4 mm, and 10.6 mm for the n-hexane extract; 8.2 mm, 10.7 mm, and 15.6 mm for the ethyl acetate extract; and 6 mm, 7.1 mm, and 14.1 mm for the methanol extract. The results of the test to determine the extract's antibacterial activity were as follows: The following is a list of the zones of inhibition that the extract has against S. aureus bacteria: 6 mm, 7.5 mm, and 13.7 mm in diameter for the extract of n-hexane; 12.8 mm, 14.2 mm, and 19.2 mm in diameter for the extract of ethyl acetate. Test results of 7.2 mm, 9.3 mm, and 15.3 mm were obtained for the methanol extract. In accordance with the findings of the study, the ethyl acetate extract of jackfruit parasite leaves exhibited the highest level of antibacterial activity, as measured by an inhibition zone diameter of 19.2 mm, when tested on S. aureus bacteria. In the meantime, the results of molecular docking of punicalin and rutin, which have been reported to have activity against proteins 6GOS.pdb and 1OJZ.pdb, have potential as antibacterials because they form 5 and 9 hydrogen bonds with important amino acids of the target protein, with cDOCKER values of -57.9239 and -88.3993, respectively. It suggests that punicalin and rutin can inhibit the growth of bacteria.</p> 2022-12-31T00:00:00+08:00 Copyright (c) 2022 Rahmiwati Hilma, Suma Rahmani Harahap, Jufrizal Syahri The Effect of Using Augmented Reality-Based Learning Media on Chemistry Students’ Conceptual Understanding on Molecular Shape 2022-12-22T08:28:55+08:00 Febrian Solikhin Dewi Handayani Salastri Rohiat <p>This study aims to examine the effect of using Augmented Reality-based learning media on students' conceptual understanding of molecular shape material. This research is a quasi-experimental study with a post-test-only design. The class used was class X Mathematics and Natural Sciences in one of the Bengkulu City High Schools, which received molecular shape material, consisting of 1 control class and 1 experimental class. The control class is a class that uses PowerPoint media as usual with 2-dimensional image visualization. In contrast, the experimental class is a class that uses augmented reality-based learning media with 3-dimensional visualization. The instrument used is a post-test instrument referring to conceptual understanding indicators. The results were analyzed using a t-test. The results of the analysis showed that the significance level was 0.002. This result indicates that it is smaller than the significance level, or it can be concluded that there is a significant difference in the average understanding of the concept between the control class and the experimental class.</p> 2022-12-31T00:00:00+08:00 Copyright (c) 2023 Febrian Solikhin, Dewi Handayani , Salastri Rohiat